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Wanshu Fan

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Review Jul 2026

Agentic AI in medicine: architectures, applications, evaluation, and challenges for clinical translation

Large language models and multimodal foundation models are enabling medical artificial intelligence (AI) systems to move beyond isolated prediction and undertake multistep clinical tasks that require planning, tool use, memory, iterative correction, and coordination among specialized agents. However, the scope of agentic AI in medicine remains unsettled, and current evaluation practices are not yet aligned with the requirements of clinical use. We conducted a scoping review with systematic evidence mapping across five electronic sources, screened 1,649 exportable records, and provisionally included 557 unique studies that met predefined criteria for goal-directed task execution, tool use, interaction with external resources, feedback-based refinement, or multi-agent collaboration. The included studies describe single agents that use external tools, workflows supported by retrieval and external knowledge, multimodal agents, and multi-agent systems applied to medical question answering, image interpretation, electronic health record analysis, drug safety, and clinical trial prediction. The evidence base remains dominated by public benchmarks, simulated settings, retrospective datasets, and small-scale expert evaluation. Process reliability, evidence traceability, uncertainty, safety, workflow impact, and external validity are evaluated less consistently. Clinical translation will depend on clearer definitions, reproducible evaluation, auditable oversight, interoperable system design, and prospective validation in real-world clinical workflows.

Zheng Tong, Yang Liu, Wanshu Fan et al. · 0 citations
Jul 2026

MambaLIE: Scene Light Intensity-Boosted Low-Light Image Enhancement with State Space Model

Images captured by consumer electronic devices, such as mobile phones and digital cameras, often suffer from low-light degradation due to sensor limitations and imaging pipelines, which degrades visual quality and affects downstream vision tasks. Existing methods based on Convolutional Neural Networks (CNNs) and Transformers have dominated current low-light image enhancement (LIE) due to their excellent ability to model hierarchical features. However, CNNs operate in local receptive fields that cannot model long-range dependencies, while Transformers overcome this problem but incur substantial computational costs. To address these challenges, we propose MambaLIE, a Scene Light Intensity-Boosted Low-Light Image Enhancement method based on a State Space Model (SSM). We first introduce scene light intensity to improve the structural distribution of illumination, which is then gated with the low-light input to guide enhancement. To better model the illumination while maintaining computational efficiency, we propose the Locally Enhanced State Space Model (LESSM) for efficient light enhancement. Our LESSM contains two branches: an SSM branch and a Local Enhanced branch, where the former is used to model the long-range dependencies with linear time complexity, while the latter is used to enhance local feature representations. Extensive experiments demonstrate that MambaLIE outperforms state-of-the-art CNN-based and Transformer-based LIE methods on four widely used synthetic benchmarks and five publicly available real-world benchmarks in terms of accuracy, speed, and model size, making it suitable for practical deployment on resource-constrained devices.

Wanshu Fan, Xiangyu Li, Cong Wang et al. · 0 citations