Author

Wanzhou Wang

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Open access Jan 2026

Multiomics Profiling Identifies Tlr4 as a Therapeutic Target of Necroptosis in Spinal Cord Injury

This study is the first to establish Tlr4 as a direct upstream regulator of the pRIPK1/pRIPK3/pMLKL necroptotic axis in SCI, distinct from its role as a general inflammatory mediator, suggesting Tlr4 as a promising therapeutic target for functional recovery.

Wanzhou Wang, Lu Sun, Wei Xie et al. · Mediators of Inflammation · 0 citations