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Wathiq Al-hachami

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Open access Aug 2026

Design, synthesis, characterization, molecular docking, MM-GBSA analysis, and molecular dynamics simulation of novel coumarin-hydrazone derivatives as potential carbonic anhydrase inhibitors

Tumor-associated carbonic anhydrases (CAs), particularly CA IX and CA XII, are relevant molecular targets because of their role in pH regulation within the tumor microenvironment. In this study, six coumarin-based hydrazide-hydrazone derivatives (AT1–AT6) were designed and synthesized from 6-aminocoumarin through chl...

Ayuub J. Mohammed, Noor H. Naser, Wathiq Al-hachami · 0 citations

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