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Wei-Bing Zhu

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Open access Aug 2026

The multimodal antidepressant vortioxetine exerts therapeutic effects in male mice which is associated with normalization of hippocampal SIK2/CRTC1-related signaling and require hippocampal CRTC1

Introduction The multimodal antidepressant vortioxetine combines serotonin reuptake inhibition with activity at several serotonin receptor subtypes, yet its downstream mechanisms related to neuroplasticity remain incompletely understood. This study investigated whether vortioxetine’s antidepressant efficacy involves hi...

Hui Xu, Hua Fan, E-Hui Ding et al. · 0 citations

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