Wei-Dan Chen

N6-methyladenosine epitranscriptomic remodeling drives infantile aortic coarctation via FTO-mediated repression of PTEN and GRK5

Introduction Aortic coarctation (CoA) is a prevalent congenital heart defect defined by focal aortic narrowing and progressive fibrosis, associated with substantial long-term cardiovascular morbidity. Although surgical repair improves early survival, the molecular and epigenetic mechanisms governing CoA pathogenesis re...