A organelle-centered perspective will clarify AD pathogenesis and help guide the development of next-generation neuroprotective therapies, and highlight the essential requirements for building one, centered on synaptic mitochondrial bioenergetics and quality control.
Yu-Xin Wang, Wei-Dong Wu, Li-Shuang Yan et al.· Frontiers in Pharmacology· 0 citations
Shared molecular mechanisms, including pattern-recognition receptor signaling, metabolic reprogramming, inflammasome activation, cytokine networks, and the shift from immune tolerance to inflammation are discussed.
Fangfang Jin, Wei-Dong Wu, Xuan Yang et al.· International Journal of Mol...· 0 citations
AD is a complex neurodegenerative disorder characterized by chronic neuroinflammation. Microglia, the brain’s resident immune cells, centrally regulate AD pathophysiology. Recent studies have highlighted microglial mitophagy as an important interface linking mitochondrial quality control to innate immune responses.Inta...
Ming-Yue Zou, Teng-Yu Zhao, Wei-Dong Wu et al.· Journal of Neuroinflammation· 0 citations
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