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Open access Oct 2026

Accessibility and Alignment of Trans-Cleavage Substrates Modulate the Kinetics of Cas12a Ribonucleoprotein.

Mechanistic understanding of molecular interactions involved in the trans-cleavage of CRISPR ribonucleoprotein systems is critical to advance genome editing, cell imaging, DNA nanotechnology, and molecular diagnostics. However, the mechanisms underlying molecular interactions of the substrate with the ribonucleoprotein...

Jian-Yu Hu, Wei Feng, Hong-Quan Zhang et al. · 0 citations

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