Aug 2026
Circ_PRKCA Drove NSCLC Progression via SRSF1/HIF-1A/PKM2 Axis-Mediated Glycolytic Reprogramming.
The data suggest that circPRKCA may act as a scaffold for RNA-binding proteins (RBPs), potentially facilitating the recruitment of SRSF1 to HIF-1A mRNA, which appeared to correlate with increased HIF-1A stability, and reveal novel diagnostic biomarkers and therapeutic strategies for NSCLC.
Hai-Ting Chen, Xing-Xing Jin, Leilei Tao et al.
· Experimental Cell Research · 0 citations