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Sponsored AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI

Author

Wei Gao

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Review Open access Sep 2026

Pharmaceutical Industry Perspectives on Exposure‐Response Confounding in Large Molecule Therapeutics: Results From an IQ Consortium Survey

Exposure‐response (ER) analyses assessing the efficacy of large molecule therapeutics are often susceptible to confounding, where associations between drug exposure and patient disease severity can obscure true ER signals and complicate dose selection. To better understand the pharmaceutical industry perspectives on th...

Engie Salama, M. Lamba, Sihem Ait-Oudhia et al. · 0 citations
Open access Jul 2026

Construction of a translational whole-body physiologically based pharmacokinetic model to investigate the biodistribution of lipid nanoparticle-based mRNA therapeutics for intracellular protein targets

This whole-body PBPK framework provides a mechanistic and predictive platform to support first-in-human dose selection, to interrogate multilevel determinants of mRNA pharmacokinetics, and to guide rational mRNA-LNP design.

Kenji Miyazawa, H. Bazzazi, Wei Gao · 0 citations

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