Open access
Sep 2026
SYVN1-mediated succinate accumulation exacerbates heart failure.
Metabolic remodeling, defined as changes in the energy substrate preferences and energy production efficiency of the myocardium, is one of the pathogenic characteristics of failing hearts, though its molecular mechanisms remain incompletely understood. Through untargeted metabolomics coupled with targeted mass spectrom...
Hong-Tu Cui, Lu Fang, Huan-Huan Cao et al.
· Science China Life Sciences · 0 citations