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Author

Wei Guan

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Review Sep 2026

From Structural Resolution to Functional Elucidation: Research Progress of GPR158 as a Target for Antidepressant Drug Development.

Findings in this review reveal the potential regulatory function of GPR158 in the pathological process of depression and provide a solid theoretical basis for the development of antidepressant drugs targeting GPCRs, facilitating the subsequent development of more accurate and efficient antidepressant candidate drugs.

Wei Guan, Ya-Bin Zheng · 0 citations
Review Jul 2026

Targeting RIPK1 for the treatment of depression: From neuroinflammation to synaptic plasticity.

This review discusses the mechanisms by which RIPK1 participates in the pathological process of depression, including its role in neuroinflammation and synaptic plasticity, and outlines the effects of RIPK1 inhibitors in animal models.

Xiao-Qun Chen, Yu-Chi Zhuang, Wei Guan · 0 citations

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