Author

Wei-Guo Liu

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Open access Sep 2026

Non-motor correlates of anxiety in de novo Parkinson’s disease: a cross-sectional study with exploratory subgroup analyses

Anxiety is a prevalent early non-motor symptom of Parkinson’s disease (PD), but its clinical correlates remain poorly defined in de novo , drug-naïve patients. This retrospective cross-sectional study enrolled 284 medication-naïve de novo PD patients and 147 age- and sex-matched healthy controls to identify n...

Gui-Xiang He, Gen-Di Wang, Hai-Hua Sun et al. · Frontiers in Neuroscience · 0 citations

Open access Jul 2026

Local brain network alterations in prodromal and De Novo Parkinson's disease: basal ganglia functional connectivity mediates the association between regional homogeneity and motor manifestations.

Along with the transition from the prodromal to the manifested period and the development of motor signs, network alterations of BG loop may play an important mediating role between local alterations in occipital-related brain regions and tremor performance.

Zhi-Ying Guo, Jingzhe Li, Jianxia Xu et al. · Behavioral and Brain Functio... · 0 citations

Open access Aug 2026

Cortical and subcortical morphological alterations in de novo GBA-related Parkinson’s disease

GBA-PD patients showed distinct patterns of cortical thickness and volume thinning, as well as amygdala subregional atrophy, which may contribute to future exploratory phenotypic characterization or patient stratification, but validation in larger independent cohorts is required.

Jing-Ru Ren, Yi Xing, Hao Zhou et al. · Frontiers in Aging Neuroscie... · 0 citations