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Sep 2026

Sodium fluoride induces hepatic and intestinal injury via gut microbiota dysbiosis and inflammatory activation: insights from network toxicology and 16S rRNA sequencing.

Fluoride is an essential trace element for human health. However, excessive intake of sodium fluoride (NaF) can induce fluorosis and lead to liver and intestinal injury. The mechanisms underlying NaF-induced hepatic and intestinal damage remain unclear. In this study, network toxicology was integrated with 16S rRNA hig...

Xing-Yan Du, Xiao-Yue Zhang, Yuan-Yuan Xiao et al. · 0 citations
Open access Jul 2026

Pleiotropic roles of the MATE transporter CD20030 in Clostridioides difficile: linking multidrug resistance to oxidative stress defense and virulence regulation

The MATE transporter (CD20030) operates as a pleiotropic regulatory hub and metabolic sentinel in C. difficile, indicating the involvement of this transporter in intrinsic resistance and oxidative defense and presenting a “swimming-to-sliding transition” driven by metabolic stress, rather than active swimming motility.

Jie Deng, Fa-Hui Chen, Wen-Jing Wu et al. · 0 citations

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