Gastrointestinal malignancies remain leading causes of cancer mortality, yet their sensitivity to immunotherapy differs sharply across anatomical sites, histologies, molecular subtypes, and disease stages. Immune checkpoint blockade has established durable clinical benefit in microsatellite instability-high colorectal...
Bo Liu, Lei Wang, Yue-Han Ma et al.· Frontiers in Immunology· 0 citations
Ifupinostat (BEBT-908) is a novel dual-targeted inhibitor of histone deacetylase (HDACs) and phosphatidylinositol 3-kinase alpha (PI3Kα). We evaluated the efficacy and safety of ifupinostat monotherapy in patients with relapsed or refractory (r/r) diffuse large B-cell lymphoma (DLBCL) after at least 2 prior lines of sy...
Yuan-Kai Shi, Peng Liu, Yu-Fu Li et al.· Signal Transduction and Targ...· 0 citations
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