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Author

Wei-Jie Zhang

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Oct 2026

Targeting ZDHHC15-mediated S-acylation of CD155 reactivates anti-tumor immunity.

The immune checkpoint CD155 is frequently upregulated across multiple malignancies and drives tumor progression and immune evasion, yet the posttranslational mechanisms regulating its stability and activity remain unclear. Here, we identify S-acylation as a key regulator of CD155 stability and immunosuppressive functio...

Xuan-Pu Zhang, Jie Zou, Jian Lin et al. · 0 citations

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