Author

Wei-Jing Liu

3 papers indexed here

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Aug 2026

M-SYFSF attenuates diabetic kidney disease by suppressing Piezo1-associated cGAS-STING signalling and tubular pyroptosis.

BACKGROUND Diabetic kidney disease (DKD) is a major cause of chronic kidney disease (CKD) worldwide, characterised by tubular injury, inflammation, and fibrosis. Increasing evidence suggests that mechanotransduction and innate immune activation contribute to DKD progression. However, the mechanistic link between mechan...

Yaotan Li, Jinyi Hou, Xiaochang Wu et al. · Phytomedicine · 0 citations

Sep 2026

A hypoxia-derived seven-gene signature reflects immune remodeling in diabetic kidney disease: integrated transcriptomic analysis and experimental validation.

AIMS To develop and assess a hypoxia-associated gene signature for diabetic kidney disease (DKD), and to examine its relationship with immune remodeling and molecular heterogeneity. METHODS GEO renal transcriptomic datasets were integrated to identify hypoxia-related differentially expressed genes. Weighted gene co-e...

Yue Ji, Jia-Kun Zhang, Xi Guo et al. · Diabetes Research and Clinic... · 0 citations

Open access Jan 2026

Mechanistic Elucidation of Yiqi Yangyin Qingre Decoction in Diabetic Nephropathy Therapy via Network Pharmacology and In Vivo Validation

YQYYQR exerts a protective effect against DN progression by targeting core genes including GSK3β, regulating the GSK3β‐TFEB axis to restore autophagic flux via the autophagy‐lysosomal pathway, and inhibiting NLRP3‐mediated pyroptosis to mitigate excessive renal inflammation.

Shu-Jiao Zhang, Yiran Xie, Jingyi Tang et al. · Journal of Diabetes Research · 0 citations