Author

Wei-Li Yang

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Review Open access Sep 2026

Species-dependent activities of the PINK1–parkin axis

In vitro studies have established that PTEN-induced putative kinase 1 (PINK1) and parkin are central regulators of mitophagy, and loss-of-function mutations in either gene can cause early-onset Parkinson’s disease (PD). Although various animal models, including mice and pigs with PINK1 or PRKN knockout, have largely fa...

Wei Huang, Ke-Cheng Chen, Jia-Yi Wen et al. · Translational Neurodegenerat... · 0 citations

Aug 2026

Multimodal brain cell atlas across the adult macaque lifespan.

A comprehensive transcriptomic and chromatin accessibility atlas of 8 brain regions of 23 female cynomolgus macaques spanning the adult lifespan, including exceptionally old individuals establishes a foundational framework for understanding the cellular and regulatory architecture of primate brain aging and its links t...

Xiao Zhang, Guang-Shun Lai, Xiang-Yu Guo et al. · Cell · 0 citations