SIRT3 regulates GLS1 K311 acetylation to restrain glutamate-driven ferroptosis in renal fibrosis.
Renal tubulointerstitial fibrosis is a final common pathway of chronic kidney disease (CKD), but the metabolic mechanisms linking mitochondrial dysfunction to ferroptotic tubular injury remain incompletely defined. We found that a SIRT3-GLS1-glutamate-p53/SLC7A11 pathway links mitochondrial deacetylation to ferroptosis...