Abstract B040: Hold-to-Kill: RIPTAC Expanding Induced Proximity from Target Engagement to Therapeutic Window
RIPTAC (Regulated Induced Proximity Targeting Chimeras) introduces a novel strategy that leverages induced proximity to achieve selective cancer cell killing. Using AR-BRD4 RIPTAC II-5 as a tool compound, we integrated biochemical screening, computational docking, and multi-level cellular and in vivo assays to establ...