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Author

Wei Liu

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Sep 2026

Tetramethylpyrazine ameliorates metabolic dysfunction-associated steatohepatitis by modulating gut microbiota dysbiosis and restoring intestinal barrier integrity.

BACKGROUND AND PURPOSE This study investigated the therapeutic effects and gut-liver axis-related mechanisms of tetramethylpyrazine (TMP) in metabolic dysfunction-associated steatohepatitis (MASH). EXPERIMENTAL APPROACH Male C57BL/6 mice were fed a methionine- and choline-deficient (MCD) diet for 6 weeks to establish...

Xiao-Li He, Linzhang Zhang, Ya-Di Zhu et al. · 0 citations
Aug 2026

Polyporus umbellatus β-glucan ameliorates metabolic dysfunction-associated steatohepatitis by remodeling the gut microbiota-bile acid-FXR signaling axis.

PUP alleviates MASH via a gut microbiota-BSH-BA-FXR axis by remodeling the gut microbiota, enhancing BSH-dependent BA metabolism, and restoring physiological FXR feedback signaling.

Wei Gao, Jie-Wen Shi, Li-Juan Xie et al. · 0 citations

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