Author

Weiqiang Zhou

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Open access Oct 2026

IL-6 Blockade with Clazakizumab is Associated with Low Myeloid Cell Activation and Increased Type 2 Immune Responses in Non-survivors of COVID-19.

BACKGROUND IL-6 inhibitors have been associated with reduced mortality in severe COVID-19 in randomized clinical trials, but the comprehensive immunological impact of IL-6 blockade in the setting of an acute viral infection is poorly understood. METHODS To gain insight into the systemic immune response to IL-6 inhibi...

Laila Stoddart, T. Johnston, Wei-Qiang Zhou et al. · Journal of Infectious Diseas... · 0 citations

Open access Sep 2026

Sex and age differences in antibody responses to seasonal influenza vaccination are mediated by estrogenic upregulation of NF-κB and TNF signaling in B cells

ABSTRACT Sex differences in the humoral immune responses to the seasonal quadrivalent influenza vaccine (QIV) in young adults (YA; 18–49 years old) or high-dose QIV in old adults (OA; 75+ years old) were analyzed to determine how age-related changes, including in steroids, impact sex differences in B cells. Among YAs,...

Han-sol Park, Anna Yin, Weiqiang Zhou et al. · mBio · 0 citations

Open access Jul 2026

CpG-Adjuvanted Heplisav-B Induces Strong Th1-Biased Innate Responses Compared to Alum-Adjuvanted HBV Vaccines in PLWH 2308661

Heplisav-B induces stronger Th1-skewed innate responses and increased B cell frequency than Engerix-B in PLWH within the first 24 hours of vaccination, while overall cellular composition and activation remain largely preserved.

Jenny M. Lee, Prasanthy Balasubramanian, Yufeng Liu et al. · Journal of Immunology · 0 citations