Total glucosides of paeony ameliorate cognitive impairment by promoting ketogenesis and modulating Glu-AMPAR signaling.
Impaired cerebral energy metabolism and synaptic dysfunction are closely associated with cognitive decline in Alzheimer's disease (AD). Although total glucosides of paeony (TGP) have demonstrated neuroprotective properties, whether TGP protects synaptic function through regulation of cerebral energy metabolism remains...