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Author

Wei Song

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Open access Sep 2026

Triggering SORL1 Expression Restricts ccRCC Progression by Inducing Ubiquitination‐Mediated c‐Myc Degradation

ABSTRACT Clear cell renal cell carcinoma (ccRCC) represents one of the most prevalent malignancies worldwide, characterized by high incidence and mortality rates. It is characterized by mitochondrial dysfunction with enhanced Warburg effect. In this study, we identify the sortilin‐related receptor 1 (SORL1) as a regula...

Ke-Yi Wang, Wei Song, Q. Bai et al. · 0 citations
Open access Sep 2026

ZBTB10 inhibits ccRCC progression by epigenetically silencing GPX4 through a self-regulatory ZBTB10/DNMT1/FBXW4 loop

ZBTB10 is identified as a suppressor of ccRCC progression that transcriptionally represses GPX4, a central inhibitor of ferroptosis and an epigenetic mechanism linking ZBTB10 to ferroptosis in ccRCC is revealed and targeting the ZBTB10/DNMT1/FBXW4/GPX4 axis may provide a therapeutic strategy for limiting ccRCC progress...

Wei Song, Hou-Liang Zhang, Yi-Di Wang et al. · 0 citations

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