Open access
Jul 2026
A dual-receptor checkpoint primes enterovirus D68 for respiratory cell entry
Cryo-EM structures of historical and contemporary AFM-associated EV-D68 strains, together with their complexes bound to the third extracellular loop of MFSD6, reveal a glycan-mediated dual-lock mechanism that may enhance receptor specificity, prevent premature uncoating, and ensure productive infection only upon engage...
Shengjian Liang, Hao-Ran Guo, Zhili Xu et al.
· Nature Communications · 0 citations