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Sep 2026

AMD1 regulates cysteine metabolism and ferroptosis sensitivity in rheumatoid arthritis fibroblast-like synoviocytes.

BACKGROUND Rheumatoid arthritis (RA) is characterized by synovial inflammation and hyperplasia, with fibroblast-like synoviocytes (FLS) playing a key pathogenic role. Cysteine metabolism is central to redox homeostasis and ferroptosis regulation, yet its mechanisms in RA-FLS remain poorly understood. This study investi...

L. Su, Jun Du, Fu-Min Qi et al. · 0 citations
Open access Sep 2026

Dysregulation of the cytotoxic-humoral axis and expansion of regulatory T cells in anti-TIF1γ- positive dermatomyositis

Introduction Dermatomyositis (DM), particularly the anti-TIF1γ‑positive subtype, is associated with a substantially elevated risk of malignancy. However, the peripheral immune landscape of this autoantibody-defined subset, especially in patients without concurrent cancer, remains incompletely understood. Methods We per...

Xiao-Guang Cui, Kai-Hong Ye, Hong Wang et al. · 0 citations

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