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Open access Sep 2026

CAF-derived BHB modulates FXR1-Kbhb and NK-cell lipid metabolism in osteosarcoma

Osteosarcoma (OS) is the most common primary malignant bone tumor in children and adolescents and is characterized by high aggressiveness and poor prognosis. Although surgery and chemotherapy have improved overall survival, outcomes for relapsed or metastatic disease remain extremely poor, thus underscoring the urgent...

Yi-Han Yu, Wei Wu, An-Zhen Ju et al. · 0 citations
Review Jul 2026

Navigating the cGAS-STING signaling pathway in breast cancer: Reinterpreting the paradox of antitumor and pro-metastatic.

The cGAS-STING signaling pathway exhibits functions in breast cancer that include both antitumor immunity and pro-metastatic inflammation, transcending traditional linear switch models. To address this cognitive bottleneck, this paper proposes the conceptual framework of "cGAS-STING pathway-guided signal flow." It attr...

Yu-Xuan Xiao, Junjia Gao, Zi-Xu Zhang et al. · 0 citations

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