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Weixi Gao

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Book Open access Aug 2026

VCAgent: A Mutation-Guided Self-Reflective Agent Framework for Virtual Cell Modeling

Large Language Models (LLMs) are increasingly used for agent-based virtual cell modeling, yet existing frameworks rely on unstructured retrieval or static prompt engineering, injecting noisy evidence and wasting inference budget on redundant tool-use trajectories. We propose VCAgent, a self-evolving framework that opti...

Zhiyun Li, Rong Han, Xiao-Yong Wang et al. · 0 citations
Book Open access Aug 2026

VCAgent: A Mutation-Guided Self-Reflective Agent Framework for Virtual Cell Modeling

VCAgent is proposed, a self-evolving framework that optimizes how biological knowledge from external APIs is structured and integrated into LLM reasoning, and introduces a schema-based slot filling mechanism that transforms raw API responses into compact, typed representations, replacing unstructured text concatenation...

Zhiyun Li, Rong Han, Xiao-Yong Wang et al. · 0 citations

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