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Open access Aug 2026

Mechanistic Insights into Aldose Reductase-Dependent Modulation of Hypoxia-Inducible Factor-1α in Promoting Renal Fibrosis

Renal fibrosis (RF) represents the common pathological endpoint of all chronic kidney diseases. According to recent evidence, impaired mitophagy, which facilitates epithelial-mesenchymal transition (EMT) in renal tubular epithelial cells (RTECs), substantially contributes to RF progression, although the underlying mech...

Wen-Ke Zhao, Hao-Yu Wang, Jing-Jing Yan et al. · 0 citations

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