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Sep 2026

In vivo CRISPR screens identify the glutamine transporter SLC1A5 as a metabolic barrier to antitumor immunity.

Tumor cells often evade immune pressure via metabolic reprogramming, yet the key metabolic regulators orchestrating this process remain incompletely defined. Here, using in vivo metabolic CRISPR screening under distinct immune pressures, we identified tumor cell-intrinsic solute carrier family 1 member 5 (SLC1A5) as a...

Wen-Long Jia, Guan-Xing Yu, Shen-Qi Han et al. · 0 citations
Open access Sep 2026

Guanine promotes acute lung injury by repressing H3K27me3 in sepsis.

The findings reveal that circulating G6PD promotes lung injury by rewiring purine metabolism and remodeling the epigenetic profile in sepsis, shedding light on the critical role of EVs as a pro-inflammatory signal and targeting G6PD for future sepsis diagnosis and treatment.

Chao-Qun Wang, Hui-Juan Wang, Yue-Yu Kong et al. · 0 citations

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