Open access
Sep 2026
SIRT7 upregulation protects against TKI-induced cardiotoxicity by inhibiting MCU-mediated mitochondrial calcium overload
Background Tyrosine kinase inhibitors (TKIs) are potent anticancer agents; however, their clinical application is often restricted because of cardiotoxic effects. The mechanisms underlying cardiotoxicity that are shared across different TKIs remain inadequately understood. Purpose This study aimed to investigate the ro...
Mei-Ling Gao, Zhe Wang, Zhi-Ling Cheng et al.
· Frontiers in Pharmacology · 0 citations