Nav1.3 inhibition confers neuroprotection in traumatic brain injury by attenuating neuroinflammation and neuronal cell death via NCOA4-associated ferritin turnover.
Our previous investigations using antisense-mediated knockdown supported a pathogenic role for the voltage-gated sodium channel isoform Nav1.3 in traumatic brain injury (TBI), yet its downstream mechanisms remain incompletely defined. Here, we observed concurrent elevation of Nav1.3 mRNA and Ca2+ in human brain tissues...