Spatial synaptic pruning mechanism of NAC microglia in differential regulation of PTSD- and depression-like behaviors.
BACKGROUND AND AIMS Post-traumatic stress disorder (PTSD) comorbid with depression is a prevalent, treatment-refractory clinical syndrome. Emerging evidence indicates shared microglial alterations in PTSD and depression, suggesting it may represent a common pathological substrate. However, the underlying neuroimmune me...