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Open access Oct 2026

TAK1 Is Associated with Lipid-Induced Macrophage Polarization in Obesity Cardiomyopathy: Evidence from Network Pharmacology and Experimental Validation

Objective: To investigate whether TAK1 regulates lipid-induced macrophage polarization and contributes to inflammatory progression in obesity cardiomyopathy (OCM). Background: OCM is characterized by lipid overload, chronic low-grade inflammation, macrophage polarization imbalance, and myocardial remodeling. Preliminar...

Cong-Xiang Yi, Ye Pu, Di Chen et al. · 0 citations
Review Open access Sep 2026

Altered Acylcarnitine Metabolism in cardiac diseases: From molecular mechanisms to translational potential

Cardiovascular diseases (CVDs) are a leading global cause of mortality and disease burden, closely associated with the remodeling of myocardial energy metabolism. Acylcarnitines (Acs) are key intermediates in the carnitine shuttle and fatty acid β-oxidation (FAO) processes. They play a critical role in transporting lon...

Jia-Zhen Wu, Yi Zhang, Jia-Wei Liu et al. · 0 citations

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