Author

Wei Zheng

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Open access Sep 2026

Cellular modifiers of TDP-43 phase transition and cytoplasmic aggregation

RNA-binding protein TAR DNA-binding protein 43 (TDP-43) can form liquid-like nuclear assemblies whose phase behavior is thought to influence its aggregation propensity and neurotoxic activity. The mechanisms that govern the liquid-to-solid phase transition of TDP-43 remain poorly defined. Here, we combined chemical and...

Natalie Chin, Qi Zhang, Ji-Zhong Zou et al. · eLife · 0 citations

Open access Jul 2026

In vitro bioactivity profile-driven discovery of drug synergies in hepatocellular carcinoma

A data-driven workflow to integrate two orthogonal single-agent resources for 244 drugs, including cell viability profiles across 11 liver cancer cell lines and bioactivity signatures across 1,925 biochemical and cell-based assays is developed.

Tuan Xu, Miao Xu, Deborah K. Ngan et al. · Journal of Translational Med... · 0 citations