The Role of Ginsenosides in Obesity-Associated Sarcopenia: Focus on E3 Ubiquitin Ligase-Mediated Regulation of Protein Homeostasis.
Obesity-associated sarcopenia (OAS) is a complex metabolic disorder characterized by excessive adiposity accompanied by progressive skeletal muscle loss, largely driven by impaired protein homeostasis. The ubiquitin-proteasome system (UPS) plays a central role in this process, with E3 ubiquitin ligases such as Atrogin-...