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Open access Oct 2026

Longitudinal peripheral immune dynamics during anti-programmed cell death 1 neoadjuvant therapy in esophageal squamous cell carcinoma

Introduction Anti-programmed cell death 1 (PD-1)-based neoadjuvant therapy is increasingly used for esophageal squamous cell carcinoma (ESCC), but paired peripheral immune dynamics and their exploratory relationship to response remain incompletely characterized. Methods We performed a retrospective longitudinal flow-cy...

Lin-Peng Li, Ling-Wen Meng, Xin-Ru Chen et al. · 0 citations
Open access Oct 2026

A multicohort proteomics-based machine learning score (MASHPredict) for noninvasive diagnosis and long-term prognostication of metabolic dysfunction-associated steatohepatitis

Metabolic dysfunction-associated steatohepatitis (MASH) can progress to cirrhosis and hepatocellular carcinoma, yet the invasiveness of liver biopsy limits its clinical utility. Accurate noninvasive diagnostic tools are essential for improved patient risk stratification. A machine learning study was conducte...

Xu Hu, Fan-Lai Meng, Wei Zhou et al. · 0 citations

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