Author

Weidong Liu

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Jul 2026

Ischemia-induced p300-dependent histone lactylation activates an AP-1-SPP1 program in microglia to exacerbate ischemic brain injury.

A lactate-p300-AP-1-SPP1 axis that couples ischemic metabolism to microglial chromatin remodeling and post-stroke neuroinflammatory injury is defined.

Meng Zhang, Huiyuan Zhang, Weidong Liu et al. · International Journal of Bio... · 1 citation