A bifunctional mitochondria-targeted iridium(III) complex for nitroreductase detection in living cells and photodynamic therapy of cancer cells.
Nitroreductase (NTR) can efficiently reduce the nitro group of compounds to an amino group using nicotinamide adenine dinucleotide (NADH) as an electron source. Its expression is upregulated under hypoxic conditions, making it a reliable marker for the degree of hypoxia in tumor cells. Herein, we designed and synthesiz...