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Open access Oct 2026

A Mendelian randomization study reveals TNF-β as a potential protective factor against sarcopenia

Sarcopenia, defined by the loss of muscle mass and strength, significantly impacts the elderly and is linked to chronic inflammation. The exact causal relationship between circulating inflammatory factors and sarcopenia is not yet clear. We employed a 2-sample Mendelian randomization analysis using 91 circulating infla...

Zheng-Lin Mei, Yue Wan, Xin-Ning Mao et al. · 0 citations
Open access Aug 2026

Mendelian randomization and drug repurposing analysis identifies APOE as a potential therapeutic target for low back pain

Low back pain (LBP) is a prevalent chronic pain syndrome primarily driven by spinal degeneration, causing persistent disability and reduced quality of life. Despite available interventions, identifying novel therapeutic targets remains imperative for modifying disease progression. We performed Mendelian randomization a...

Jian-Ye Yang, Weihui Qi, Dong Wang et al. · 0 citations

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