High-altitude hypoxic environments can induce significant gut microbiota dysbiosis, which in turn triggers colonic inflammation and intestinal barrier injury. This study aims to elucidate the core driving role of the gut microbiota in high-altitude induced colonic injury and to verify the protective effects of Bifidoba...
Yue-Mei Sun, Fu-Xlan Zheng, Qin-Qin Long et al.· Frontiers in Microbiology· 0 citations
Introduction High-altitude pulmonary edema (HAPE) is a severe complication of rapid exposure to high-altitude hypoxia, but its molecular mechanisms remain incompletely understood. This study aimed to characterize lung proteomic alterations in HAPE and identify candidate proteins associated with its pathophysiological p...
Dong-Mei Zhang, Ting-Ting Liu, Hong-Fang Mu et al.· Frontiers in Physiology· 0 citations
High-altitude exposure disrupts sleep, but the temporal dynamics remain poorly defined. This study characterises time‑dependent changes in sleep architecture, HPA axis function, inflammation, and central sleep‑regulatory molecules during subacute hypobaric hypoxia. Male Sprague‑Dawley rats were exposed to simulated 700...
Chang Wang, Wen Yan, Wen-fang Ma et al.· Physiology and Behavior· 0 citations
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