Structure-switching Aptamer Nanosensor for Therapeutic Drug Monitoring of Methotrexate in Diluted Serum
Methotrexate (MTX) is an anticancer drug widely used in clinical practice. Due to its narrow therapeutic index and significant interindividual variability, there is an urgent need for therapeutic drug monitoring (TDM) to mitigate adverse effects. This study aims to establish a simple, rapid, and highly sensitive fl...