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Wen-Bo Wang

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Open access Oct 2026

Lactate-Depleting Nanotherapy Reprograms the Immunometabolic Microenvironment to Overcome Biofilm Tolerance in Implant-Associated Infections.

Biofilm formation in implant-associated infections (IAIs) establishes an immunosuppressive microenvironment while conferring profound antibiotic tolerance. Through multi-omics profiling of clinical IAI samples, we identify lactate as a key metabolite associated with immunosuppression within the biofilm-associated micro...

Wen-Bo Wang, Bi-Yu Rui, Gui-Xia Wang et al. · 0 citations

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