Author

Wen-Can Wu

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Open access Oct 2026

A circRNA-microRNA-Pdcd1 axis drives microglial activation and retinal ganglion cell degeneration

These findings not only uncover a novel circRNA-mediated mechanism in neurodegeneration but also identify the circAgtpbp1-miR-3098-3p-Pdcd1-microglia axis as a promising therapeutic target for neuroprotective interventions.

Lan-Fang Sun, Xiao-Yu Ke, J.-J. Yu et al. · Communications Biology · 0 citations

Open access Jul 2026

A peripheral subpopulation of retinal pigment epithelium resists oxidative damage through SERPINE3-mediated caspase-1 inhibition

A peripheral RPE subpopulation is identified through spatial, transcriptomic, and functional analyses, thereby contributing to the understanding of the heterogeneity of degenerative RPE cells and highlighting SERPINE3 as a protective factor with therapeutic potential for macular atrophy.

Hui-Rong Li, Takerra K. Johnson-Stephenson, Vincent P. Kunze et al. · Journal of Clinical Investig... · 0 citations