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Open access Sep 2026

Development and Temporal Validation of an Interpretable Perioperative Nomogram for Prolonged Mechanical Ventilation in Older Adults Undergoing Cardiac Surgery

Background: Prolonged mechanical ventilation (PMV) after cardiac surgery reflects delayed early recovery and is associated with increased perioperative resource use. Older adults are especially vulnerable, yet practical models that jointly capture preoperative reserve and intraoperative burden remain limited. Methods:...

Shu-Kun Wang, Jun-Zhe Wang, Chen-Guang Pan et al. · 0 citations
Open access Aug 2026

CARD10 deficiency attenuates myocardial infarction associated with enhanced cardiac fibroblast senescence

It is suggested that CARD10 deficiency is associated with enhanced fibroblast senescence and improved post-MI remodeling, potentially involving mitochondrial dysfunction and PI3K/AKT signaling, highlighting CARD10 may represent a promising target for the treatment of MI.

Yueyue Xu, Yiwei Yao, Yue-Yun Zhou et al. · 0 citations

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