Author

Wendan Yi

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Open access Sep 2026

Benzyl isothiocyanate alleviates neural damage in experimental autoimmune uveitis by modulating the TREM-1/PI3K/AKT signaling pathway

Purpose: To investigate whether Benzyl isothiocyanate (BITC) can improve experimental autoimmune uveitis (EAU) and explore its potential mechanism. Methods: To evaluate the therapeutic efficacy of BITC, EAU was induced in C57BL/6 mice via immunization with IRBP 651-670 . Clinical scores and histopathological s...

Si-Jie Liu, Wen-Dan Yi, Yi-Qing Ji et al. · Frontiers in Pharmacology · 0 citations

Open access Aug 2026

Benzyl isothiocyanate alleviates endotoxin-induced uveitis in association with LOX-1 downregulation to modulate JAK2-STAT3 signaling, endoplasmic reticulum stress and apoptosis.

Uveitis is a sight-threatening inflammatory ocular disorder. Benzyl isothiocyanate (BITC) exhibits potent anti-inflammatory pharmacological activity. This research was designed to explore the therapeutic mechanism of BITC in acute uveitis (AU). We established a mouse model of endotoxin-induced uveitis (EIU) to evaluate...

Wen-Dan Yi, Si-Jie Liu, Hai-Yue Wang et al. · International Immunopharmaco... · 1 citation