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Wendi Huang

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Review Open access Sep 2026

TREM2-directed therapy in Alzheimer’s disease: from therapeutic window to clinical translation

It is proposed that the therapeutic value of TREM2 is best understood through the concept of therapeutic window, and soluble TREM2 (sTREM2) should be interpreted cautiously, as it may reflect receptor shedding, target engagement, microglial state, disease stage, or a combination of these processes rather than serving a...

Qi-Xia Kuang, Shu-Jun Li, Wen-Di Huang et al. · 0 citations
Review Aug 2026

Mitochondrial homeostasis dysregulation: Potential mechanisms of Alzheimer's disease mediated by TDP-43.

Key features of mitochondrial homeostasis in neurons are outlined, neuropathological and clinical data supporting the relevance of TDP-43 in AD are reviewed, and emerging mechanisms by which TDP-43 may perturb mitochondrial homeostasis are synthesized.

Wendi Huang, Juan Huang, Nan-Yu Kuang et al. · 3 citations

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