Wen-Di Shi

Key ion channels in mechanical stress-induced cardiac remodeling: from mechanotransduction to therapeutic targets

Mechanical stress—including pressure overload and volume overload—is a core pathophysiological stimulus driving cardiac remodeling, and Ca2+ signaling is the central common pathway mediating this process. Traditional research has primarily focused on L-type Ca2+ channels (LTCC) and the renin-angiotensin-aldosterone sys...