Wen-Feng Cai

Linking centromere stretch to SAC signaling in mammalian oocytes with insights from modified kinetochore model

The spindle assembly checkpoint (SAC) monitors kinetochore-microtubule interactions to ensure accurate chromosome segregation. In mitosis, investigation of its silencing at anaphase centers on whether attachment or tension is the key signal, while in meiosis for mammalian oocytes it remains unclear whether centromere...