Oral mucosal diseases often lead to structural damage and functional impairment due to high recurrence and malignant progression. Current therapeutic outcomes remain unsatisfactory owing to the complex oral microenvironment. Recent reviews have covered individual aspects of oral mucosal drug delivery, such as bioactive...
Xin Lin, Yi-Chun Zheng, Zi-Qiao Zhong et al.· Journal of Functional Biomat...· 0 citations
Oncolytic viruses hold immense therapeutic promise but face formidable systemic delivery barriers. A new study by Xu et al. engineered immunoglobulin E-sensitized mast cells to selectively ferry these viruses into tumors. Excitingly, antigen-triggered degranulation precisely releases the viral payload and reshapes the...
Skin diseases affect approximately 30%-70% of the global population and significantly reduce quality of life. Although polysaccharide-based dissolving microneedles (DMNs) are a minimally invasive transdermal delivery platform with strong clinical potential, their loose molecular packing and weak intermolecular interact...
Fan Jia, Si-Yuan Peng, Hoiian Ieong et al.· International journal of pha...· 0 citations
Central nervous system (CNS) diseases remain a therapeutic challenge due to the blood-brain barrier (BBB). The nose-to-brain pathway offers a promising non-invasive route to bypass the BBB, yet the impact of nanocarrier size on this multi-stage delivery process is poorly understood. This study systematically investigat...
Chunfu Wei, Jing Zhang, Guanlin Wang et al.· Journal of Controlled Releas...· 0 citations
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