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Primate-specific regulation of the human glycosphingolipid gatekeeper UGCG
Molecular principles for graded activation of dopamine D1 receptor
G protein-coupled receptors (GPCRs) signal across a continuum of activation states, yet how ligands encode distinct signaling efficacies remains poorly understood. Here, we define the molecular mechanism underlying graded activation of the dopamine D1 receptor (D1R), a major therapeutic target for neuropsychiatric diso...